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doi: 10.3389/fnagi.2019.00177 Received 28 February 2019 Accepted 02 July 2019 Published 08 August 2019 Volume 11 - 2019 Edited by Anne Eckert, University Psychiatric Clinic Basel, Switzerland Reviewed by Patrizia Giannoni, University of Nmes, France

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Overexpressing of FZD7 activates the oncogenic factor tumor protein 63 (TP63), leading to increased levels of glutathione metabolic pathways, including GPX4, which protects cells against chemotherapy-induced oxidative stress and ferroptosis

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